Cyclin-E1
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Cyclin-E1 Definition
Cyclin E may function at (cell cycle) START by interacting with CDC28. Cyclin E complexes with CDK2 in late G1. Cyclin-dependent kinase activation requires association with cyclins and phosphorylation by CAK, which leads to cell proliferation. Association of CDK inhibitor with a cyclin/CDK complex inhibits proliferation. CCNE1/CDK2 promotes CDKN1B phosphorylation, elimination of CDKN1B, and G1/S progression of the cell cycle. Enhanced CDKN1B inhibitory function arrests proliferation. Cyclin E is bound directly by AGO, which probably targets its ubiquitin-mediated degradation. (from OMIM 123837 and NCI)
Cyclin-E1 Synonyms
Cyclin E1, CCNE1, Cyclin E, Cyclin Es, Cyclin Et
Terms in Cyclin-E1 category
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