Cancer Terms

Cyclin-E2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin -> Cyclin-E2

Cyclin-E2 Definition

Conserved human CCNE2 Gene (Cyclin E Subfamily) encodes distinct nuclear isoforms of Cyclin E2: 1 (full-length 404-aa, 46.8-kD and 47% identical to E1), 2 (359-aa), and 3. Lacking 45 internal residues in the cyclin box, variant 2 does not bind CDK2. Frameshifted truncated variant 3 lacks 112 N-terminal residues. Imparting substrate specificity, short-lived regulatory E2 interacts with CDKs2/3, forms a holoenzyme, controls DNA synthesis, and regulates G1/S. CDK2 phosphorylation of E2 triggers release and likely ubiquitinated degradation. E2 interacts with CDK inhibitors CIP/KIP, which bind and inhibit E2/CDK2. Cyclins E1, E2 may be rate-limiting for G1 progression. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Cyclin-E2 Synonyms

Cyclin E2, CCNE2, CCNE2 Protein, G1/S-Specific Cyclin E2

Terms in Cyclin-E2 category



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