Cytarabine Hydrochloride
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Cytarabine Hydrochloride Definition
The hydrochloride form of cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
Cytarabine Hydrochloride Synonyms
Cytarabine Hydrochloride, 1-Beta-D-arabinofuranosylcytosine Hydrochloride, 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone Hydrochloride, Ara-C HCl, Arabinosylcytosine Hydrochloride, Aracytidine Hydrochloride, CHX-3311, CYTARABINE HYDROCHLORIDE, Cytosar Hydrochloride, Cytosine Arabinosine Hydrochloride, U-19920A
Terms in Cytarabine Hydrochloride category
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