Cytochrome-P450-11B2
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Cytochrome-P450-11B2 Definition
Encoded by human CYP11B2 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 11B2 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase with steroid 18-hydroxylase activity involved in preferential conversion of 11-deoxycorticosterone to aldosterone and 18-oxocortisol via corticosterone and 18-hydroxycorticosterone. CYP11B2 also has steroid 11 beta-hydroxylase activity. CYP11B2 defects cause corticosterone methyloxidase type I deficiency (CMO-I deficiency) and corticosterone methyloxidase type II deficiency (CMO-II deficiency). CYP11B2/CYP11B1 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Cytochrome-P450-11B2 Synonyms
Cytochrome P450 11B2, ALDOS, Aldosterone Synthase, Aldosterone-Synthesizing Enzyme, CYP11B2, CYPXIB2, Cytochrome P450 Subfamily XIB (Steroid 11-Beta-Hydroxylase) Polypeptide 2, Cytochrome P450 Subfamily XIB Polypeptide 2, Mitochondrial Cytochrome P450 11B2, P-450Aldo, P-450C18, Steroid 11-Beta-Monooxygenase, Steroid 11-Beta/18-Hydroxylase, Steroid 18-Hydroxylase
Terms in Cytochrome-P450-11B2 category
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