Cytochrome-P450-1A2
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Cytochrome-P450-1A2 Definition
A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.
Cytochrome-P450-1A2 Synonyms
Cytochrome P450, Family 1, Subfamily A, Polypeptide 2, Aryl Hydrocarbon Hydroxylase, CYP1A2, Cytochrome P-450, Aromatic Compound-Inducible, Cytochrome P450 1A2, Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2, Dioxin-Inducible P3-450, EC 1.14.14.1, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, P(3)450, P450 4, P450 Form 4, P450 orm 4, P450-P3, Xenobiotic Monooxygenase
Terms in Cytochrome-P450-1A2 category
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