Cancer Terms

Cytochrome-P450-2C19

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Oxidoreductase -> Cytochrome -> Cytochrome-P450 -> Cytochrome-P450-2C19

Cytochrome-P450-2C19 Definition

This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)

Cytochrome-P450-2C19 Synonyms

Cytochrome P450, Family 2, Subfamily C, Polypeptide 19, CYP2C19, CYPIIC17, CYPIIC19, Cytochrome P450 2C19, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19, EC 1.14.14.1, Flavoprotein-Linked Monooxygenase, Mephenytoin 4'-Hydroxylase, Mephenytoin 4-Prime-Hydroxylase, Microsomal Monooxygenase, P450-11A, P450-254C, Xenobiotic Monooxygenase

Terms in Cytochrome-P450-2C19 category



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