Cytochrome-P450-3A4
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Cytochrome-P450-3A4 Definition
Induced primarily in liver by glucocorticoids, drugs, pesticides, and carcinogens and encoded by human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily), Cytochrome P450 3A4 is a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Cytochrome-P450-3A4 Synonyms
Cytochrome P450 3A4, CYP3A4, Cytochrome P450 Nifedipine Oxidase, Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3, Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4, Cytochrome P450, Subfamily IIIA, Polypeptide 4, Cytochrome P450PCN1, EC 1.14.14.1, Glucocorticoid-Inducible P450, Nifedipine Oxidase, P450, FAMILY III, P450-3A4, P450-III, Steroid Inducible, P450-III, Steroid-Inducible, Quinine 3-Monooxygenase, Steroid-Inducible P450- III
Terms in Cytochrome-P450-3A4 category
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