Cytochrome-P450-8B1
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Cytochrome-P450 -> Cytochrome-P450-8B1
Cytochrome-P450-8B1 Definition
Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Cytochrome-P450-8B1 Synonyms
Cytochrome P450 8B1, 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase, CYP8B1, CYPVIIIB1, Cytochrome P450 CYP8B1, Cytochrome P450 Family 8 Subfamily B Polypeptide 1, Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1, Steroid 12-Alpha-Hydroxylase, Sterol 12 Alpha Hydroxylase
Terms in Cytochrome-P450-8B1 category
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