Cytochrome-P450-CYP11B1
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Cytochrome-P450-CYP11B1 Definition
Encoded by human CYP11B1 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 CYP11B1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase expressed in adrenal cortex with steroid 11-beta-hydroxylase activity and involved in conversion of progesterone to cortisol. The 18 or 19-hydroxylation of steroids and aromatization of androstendione to estrone have also been ascribed to CYP11B1. CYP11B1 defects cause adrenal hyperplasia type IV (AH-IV). CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Cytochrome-P450-CYP11B1 Synonyms
Cytochrome P450 CYP11B1, CYP11B1, CYPXIB1, Cytochrome P450 CYP11B2, Cytochrome P450 Subfamily XIB (Steroid 11-Beta-Hydroxylase) Polypeptide 1, Cytochrome p450 XIB1, Mitochondrial Cytochrome P450 11B1, P450C11, Steroid 11 Beta Monooxygenase, Steroid 11-Beta-Hydroxylase
Terms in Cytochrome-P450-CYP11B1 category
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