Cytochrome-P450-XVIIA1
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Cytochrome-P450 -> Cytochrome-P450-XVIIA1
Cytochrome-P450-XVIIA1 Definition
Encoded by human CYP17A1 Gene (Cytochrome P450 Family), 508-aa 57-kDa Cytochrome P450 XVIIA1 is a cAMP-regulated endoplasmic reticulum P450 heme-thiolate monooxygenase with 17alpha-hydroxylase and 17,20-lyase activity and a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Involved in fetal and adult sexual development, CYP17A1 converts pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 mutations are associated with steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia type V (AH-V). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Cytochrome-P450-XVIIA1 Synonyms
Cytochrome P450 XVIIA1, CYP17A1, CYPXVII, Cytochrome P450 Family 17, Cytochrome P450 Subfamily XVII (Steroid 17-Alpha-Hydroxylase), P450-C17, Steroid 17-Alpha-Hydroxylase, Steroid 17-Alpha-Hydroxylase/17,20 Lyase, Steroid 17-Alpha-Monooxygenase
Terms in Cytochrome-P450-XVIIA1 category
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