Cytochrome-P450-XXIB
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Oxidoreductase ->
Cytochrome ->
Cytochrome-P450 -> Cytochrome-P450-XXIB
Cytochrome-P450-XXIB Definition
Encoded by human CYP21A2 Gene (Cytochrome P450 Family), 494-aa 56-kDa Cytochrome P450 XXIB is a membrane-bound endoplasmic reticulum P450 heme-thiolate monooxygenase that hydroxylates steroids at the 21 position and is required for synthesis of steroid hormones including cortisol and aldosterone. The leucine-rich hydrophobic N-terminal region may anchor the protein. CYP21A2 defects cause congenital adrenal hyperplasia (CAH). Gene conversion events involving CYP21A2 and a nearby pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Cytochrome-P450-XXIB Synonyms
Cytochrome P450 XXIB, CYP21, CYP21A2, CYP21B, Cytochrome P450 Family 21 Subfamily A Polypeptide 2, Cytochrome P450 Subfamily XXIA (Steroid 21-Hydroxylase) Polypeptide 2, Cytosteroid 21-Monooxygenase, P450-C21B, Steroid 21-Hydroxylase
Terms in Cytochrome-P450-XXIB category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.