Cancer Terms

Cytochrome-P450C11A1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Oxidoreductase -> Cytochrome -> Cytochrome-P450 -> Cytochrome-P450C11A1

Cytochrome-P450C11A1 Definition

Encoded by human CYP11A1 Gene (Cytochrome P450 Family), 521-aa 60-kDa (precursor) Cytochrome P450C11A1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase that catalyzes a side-chain cleavage reaction conversion of cholesterol to pregnenolone, the first (rate-limiting) step in the synthesis of steroid hormones. CYP11A1 defects cause congenital adrenal insufficiency (CAI) and congenital lipoid adrenal hyperplasia (CLAH). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)

Cytochrome-P450C11A1 Synonyms

Cytochrome P450C11A1, CYP11A1, CYPXIA1, Cholesterol 20-22 Desmolase, Cholesterol Desmolase, Cholesterol Monooxygenase (Side-Chain Cleaving), Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P-450scc, Cytochrome P450 Subfamily XIA, Cytochrome P450 Subfamily XIA (Cholesterol Side Chain Cleavage), Mitochondrial Cytochrome P450 11A1, P450(scc), Steroid 20-22-Lyase

Terms in Cytochrome-P450C11A1 category



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