Cytosolic Phospholipase-A2G6
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Cytosolic Phospholipase-A2 -> Cytosolic Phospholipase-A2G6
Cytosolic Phospholipase-A2G6 Definition
Encoded as 4 alternative isoforms in distinct tissue distributions by human PLA2G6 Gene, conserved calcium-independent 806-aa 85-kD Cytosolic Phospholipase A2G6 appears to catalyze release of fatty acids from phospholipids in normal phospholipid remodeling, in NO- or vasopressin-induced arachidonic acid release, and in leukotriene and prostaglandin production; PLA2G6 may selectively hydrolyze sn-2 over sn-1 fatty acids. Cytoplasmic isoform SH-iPLA2 contains 7 ANK repeats. Isoform LH-iPLA2 is membrane bound. Ankyrin-iPLA2-1 and -2 isoforms (encoding only ankyrin repeats) lack the catalytic domain and appear to exert negative regulation on PLA2G6. PLA2G6 may participate in FAS-mediated apoptosis and in regulating transmembrane ion flux in B-cells. (NCI)
Cytosolic Phospholipase-A2G6 Synonyms
Cytosolic Phospholipase A2G6, 85kDa Calcium-Independent Phospholipase A2, CaI-PLA2, Calcium-Independent Cytosolic Phospholipase A2, Calcium-Independent Cytosolic Phospholipase A2 Group VI, Calcium-Independent Cytosolic Phospholipase A2VI, Calcium-Independent Phospholipase A2, GVI PLA2, Group VI Phospholipase A2, PLA2G6, Phospholipase A2 Group VI, Phospholipase A2VI, iPLA2
Terms in Cytosolic Phospholipase-A2G6 category
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