Cytotoxic T-Lymphocyte-Associated Protein-4

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytotoxic T-Lymphocyte-Associated Protein-4

Cytotoxic T-Lymphocyte-Associated Protein-4 Definition

CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI)

Cytotoxic T-Lymphocyte-Associated Protein-4 Synonyms

Cytotoxic T-Lymphocyte-Associated Protein 4, CD152, CD152 Antigen, CTLA-4, CTLA4, CTLA4 Protein, CTLA4-TM, Cytotoxic T-Lymphocyte Protein 4, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte-Associated Serine Esterase-4

Cytotoxic T-Lymphocyte-Associated Protein-4

Cytotoxic T-Lymphocyte-Associated Protein-4 Definition

Cytotoxic T-Lymphocyte-Associated Protein-4 Synonyms

Terms in Cytotoxic T-Lymphocyte-Associated Protein-4 category