DNA Excision Repair Protein-ERCC6
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DNA Excision Repair Protein-ERCC6 Definition
Excision Repair Protein ERCC-6 (ERCC6), encoded by the ERCC6 gene (SNF2/RAD54 Family), is a putative DNA or RNA unwinding helicase involved in transcription-coupled excision repair. This protein specifically interacts with CSA proteins and with p44, a subunit of the RNA Polymerase II basal transcription factor TFIIH. It has DNA-dependent ATP-stimulated ATPase activity that may have a role in the displacement of stalled RNA Polymerase II from sites of DNA lesion and in recruitment of a DNA repair component. ERCC6 inhibits fragility of RNU1, RNU2, and RN5S genes. p53 interacts with ERCC6 and activation of p53 inhibits ERCC6, stalling transcription complexes and blocking local chromatin condensation. Defects in ERCC6 are the cause of Cockayne's syndrome type B (CSB). (NCI)
DNA Excision Repair Protein-ERCC6 Synonyms
DNA Excision Repair Protein ERCC-6, CSB Protein, Cockayne Syndrome B Repair Protein, ERCC6, ERCC6 Protein, Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6
Terms in DNA Excision Repair Protein-ERCC6 category
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