DNA Mismatch Repair Protein-MSH2
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DNA Mismatch Repair Protein-MSH2 Definition
Alterations in MSH2 Protein are associated with DNA instability from defective repair of DNA replication errors that create mismatched nucleotides. MSH2 contains a highly conserved helix-turn-helix domain associated with an adenine nucleotide and magnesium binding motif and ATPase activity that regulates mismatch binding as a molecular switch. MSH2 protein binds DNA containing mismatches up to 14 nucleotides long. ADP-bound MSH/MSH6 binds mismatched nucleotides and ATP hydrolysis results in mismatch binding, while ADP/ATP exchange results in mismatch dissociation. MSH2 is part of the large multi-subunit BASC complex, which may sense abnormal DNA structures and/or regulate post-replication repair. MSH2 protein also interacts with G/T binding protein. MSH2 is a cloned gene for Hereditary Non-Polyposis Colon Cancer that causes colon cancer, endometrial cancer, and stomach cancer. (from OMIM and NCI)
DNA Mismatch Repair Protein-MSH2 Synonyms
DNA Mismatch Repair Protein MSH2, MSH2, MutS Homolog 2
Terms in DNA Mismatch Repair Protein-MSH2 category
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