DNA Mismatch Repair Protein-MSH3
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DNA Mismatch Repair Protein-MSH3 Definition
DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)
DNA Mismatch Repair Protein-MSH3 Synonyms
DNA Mismatch Repair Protein MSH3, DUP, Divergent Upstream Protein, MRP1, MSH3, Mismatch Repair Protein 1
Terms in DNA Mismatch Repair Protein-MSH3 category
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