DNA Mismatch Repair Protein-MSH6

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> DNA Repair Protein -> DNA Mismatch Repair Protein-MSH6

DNA Mismatch Repair Protein-MSH6 Definition

The G/T Binding Protein (GTBP), encoded by the MSH6 gene, forms Mismatch-Binding Factor with MSH2. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. (From SWISS-PROT, OMIM, and NCI)

DNA Mismatch Repair Protein-MSH6 Synonyms

DNA Mismatch Repair Protein MSH6, G/T Mismatch Binding Protein, G/T Mismatch-Binding Protein, GTBP, GTMBP, MSH6, MutS Homolog 6

Terms in DNA Mismatch Repair Protein-MSH6 category

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