DNA Replication Licensing Factor-MCM6
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DNA Replication Licensing Factor-MCM6 Definition
Widely expressed by E2F-regulated human MCM6 Gene (MCM Family), 821-aa 93-kDa DNA Replication Licensing Factor MCM6 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complex during G1, detaches from it during S phase, and prevents over-replication. Repressed in quiescent cells, MCM6 is rapidly induced at G1/S by growth factor stimulation; protein level peaks at G1/S. A stable MCM2/4/6/7 complex exhibits DNA unwinding ATPase/DNA helicase activity involved in replication initiation. MCM2/4/6/7 phosphorylation by CDC2 kinase reduces helicase activity. Hexameric MCM2-7 complex is a key element of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. (NCI)
DNA Replication Licensing Factor-MCM6 Synonyms
DNA Replication Licensing Factor MCM6, MCM6, MIS5, Minichromosome Maintenance Protein 6, P105MCM
Terms in DNA Replication Licensing Factor-MCM6 category
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