DNA Replication Licensing Factor-MCM7
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DNA Replication Licensing Factor-MCM7 Definition
Encoded by human MCM7 Gene (MCM Family), 719-aa 81-kDa DNA Replication Licensing Factor MCM7 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complexes and prevents over-replication. A stable MCM2/4/6/7 complex possesses DNA helicase activity and may act as a DNA unwinding enzyme. CDC45 binds to MCM7 and DNA polymerase alpha p70 subunit in the final sequential step of active initiation complex assembly and recruits DNA polymerase alpha to origins of replication. Nonenzymatic p70 forms a tight complex with the catalytic DNA polymerase alpha p180 subunit. The hexameric MCM2-7 complex is a key component of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. CDK4 associates with MCM7 and MCM7 binds RB1/RB. (NCI)
DNA Replication Licensing Factor-MCM7 Synonyms
DNA Replication Licensing Factor MCM7, CDC47, CDC47 Homolog, Minichromosome Maintenance Protein 7, P1.1-MCM3, P1CDC47, PNAS-146, p85MCM
Terms in DNA Replication Licensing Factor-MCM7 category
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