DNA-Directed RNA Polymerase-II Polypeptide-A
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DNA-Directed RNA Polymerase -> DNA-Directed RNA Polymerase-II Polypeptide-A
DNA-Directed RNA Polymerase-II Polypeptide-A Definition
Encoded by human POLR2A Gene (RNA Polymerase Beta Prime Chain Family), nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A is the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair.
DNA-Directed RNA Polymerase-II Polypeptide-A Synonyms
DNA Directed RNA Polymerase II Polypeptide A, DNA-Directed RNA Polymerase II Largest Subunit, POLR2, POLR2A, POLRA, Polymerase (RNA) II (DNA Directed) Polypeptide A (220kD), Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa, RNA Polymerase II 220 kD Subunit, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Terms in DNA-Directed RNA Polymerase-II Polypeptide-A category
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