Cancer Terms

DR1-Associated Protein-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> DR1-Associated Protein-1

DR1-Associated Protein-1 Definition

Encoded by human DRAP1 Gene, DR1-Associated Protein 1 is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (NCI)

DR1-Associated Protein-1 Synonyms

DR1-Associated Protein 1, DR1-Associated Corepressor, NC2-Alpha, Negative Cofactor 2 Alpha

Terms in DR1-Associated Protein-1 category



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