Dapsone Gel

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Sulfone Anti-Infective Agent -> Dapsone Gel

Dapsone Gel Definition

The 5% gel preparation of dapsone, a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.

Dapsone Gel Synonyms

Dapsone Gel, 5% Dapsone Gel, Aczone Gel, Dapsone Gel, 5%

Dapsone Gel

Dapsone Gel Definition

Dapsone Gel Synonyms

Terms in Dapsone Gel category