Dexrazoxane
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Dexrazoxane Definition
A bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.
Dexrazoxane Synonyms
Dexrazoxane, (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione), 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI), 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI), 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI), 2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI), ADR-529, DEXRAZOXANE, ICRF-187, Razoxane (+)-form, Soluble ICRF (L-isomer), dexrazoxane
Terms in Dexrazoxane category
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