Dexrazoxane Hydrochloride
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Dexrazoxane Hydrochloride Definition
The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.
Dexrazoxane Hydrochloride Synonyms
Dexrazoxane Hydrochloride, Cardioxane, DEXRAZOXANE HYDROCHLORIDE, Totect, Zinecard
Terms in Dexrazoxane Hydrochloride category
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