Diazoxide
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Diazoxide Definition
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.
Diazoxide Synonyms
Diazoxide, 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, DIAZOXIDE, Proglycem, SRG-95213
Terms in Diazoxide category
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