Dihydrosphingosine
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Dihydrosphingosine Definition
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.
Dihydrosphingosine Synonyms
Safingol, (2S,3S)-2-Amino-1,3-Octadecanediol, Kynacyte, L-(-)-threo-Sphingnine, L-Threo-Dihydrosphingosine, L-threo-2-Amino-1,3-octadecanediol, SAFINGOL, SPC-100270, Sphinganine
Terms in Dihydrosphingosine category
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