Cancer Terms

Diltiazem Malate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Cardiovascular System -> Antihypertensive Agent -> Calcium Channel Blocker -> Diltiazem Malate

Diltiazem Malate Definition

A malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.

Diltiazem Malate Synonyms

Diltiazem Malate, 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1), DILTIAZEM MALATE, Tiamate

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