Discoidin Domain Receptor-2
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Discoidin Domain Receptor-2 Definition
Encoded by human DDR2 Gene (InRTK Subfamily) and expressed in heart, lung, brain, placenta, liver, skeletal muscle, pancreas, and kidney, 855-amino acid 96.8-kD precursor Discoidin Domain Receptor 2 is a receptor tyrosine kinase for fibrillar collagen involved in cell adhesion. Mediating fibroblast migration and proliferation, the type I membrane protein contains an intracellular catalytic domain and extracellular coagulation factor 5/8 type C and discoidin domains. RTKs often transduce signals by ligand induced receptor oligomerization, intracellular autophosphorylation, and phosphorylation of cytosolic targets. DDR2 may contribute to cutaneous wound healing. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Discoidin Domain Receptor-2 Synonyms
Discoidin Domain Receptor 2, DDR2, DDR2 Protein, Discoidin Domain Receptor Family Member 2, NTRKR3, Neurotrophic Tyrosine Kinase, Receptor-Related 3, Receptor Protein-Tyrosine Kinase TKT, TKT, TYRO10, Tyrosine Kinase Receptor Related to Neurotrophic TRK, Tyrosine-Protein Kinase TYRO 10
Terms in Discoidin Domain Receptor-2 category
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