EPH Tyrosine Kinase-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> Ephrin Receptor -> EPH Tyrosine Kinase-1

EPH Tyrosine Kinase-1 Definition

EPH tyrosine kinase 1 is a member of the largest subfamily of RTKs. EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). Ephrin-A2 forms a stable complex with the metalloproteinase Kuzbanian, involving interactions outside the cleavage region and the protease domain. EPH tyrosine kinase 1 receptor binding triggers ephrin-A2 cleavage in a localized reaction specific to the cognate ligand. (from OMIM 179610 and NCI)

EPH Tyrosine Kinase-1 Synonyms

EPH Tyrosine Kinase 1, EC 2.7.1.112, EPHA1, Ephrin Receptor EphA1, Ephrin Type-A Receptor 1, Erythropoietin-Producing Hepatoma Amplified Sequence, Receptor Tyrosine Kinase EPH, Tyrosine-Protein Kinase Receptor EPH

EPH Tyrosine Kinase-1

EPH Tyrosine Kinase-1 Definition

EPH Tyrosine Kinase-1 Synonyms

Terms in EPH Tyrosine Kinase-1 category