ERBB2 Receptor Protein-Tyrosine Kinase
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ERBB2 Protein -> ERBB2 Receptor Protein-Tyrosine Kinase
ERBB2 Receptor Protein-Tyrosine Kinase Definition
The ERBB2 gene encodes a putative tyrosine kinase growth factor receptor EGFR2, p185 HER2/NEU antigen, similar to the EGF receptor. The ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptors, members of the EGFR-related type I receptor tyrosine kinase subfamily. The encoded proteins form homo- and heterodimers, which complicates assignment of function: ERBB2 homodimers do not bind heregulin, but ERBB2/ERBB3 heterodimers do. Herstatin is a secreted alternative ERBB2 product, of the extracellular domain, that binds to p185ERBB2, disrupts ERBB2 dimers, reduces p185 phosphorylation, and inhibits growth. Human ERBB2 gene is located at 17p12-21. Overexpression of HER-2 correlates with poor prognosis in breast carcinoma.
ERBB2 Receptor Protein-Tyrosine Kinase Synonyms
ERBB2 Receptor Protein-Tyrosine Kinase, ERBB2, HER-2, HER2, NEU, c-erbB-2
Terms in ERBB2 Receptor Protein-Tyrosine Kinase category
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