Cancer Terms

EWS-FLI1 Type 1

Cancer Terms -> Retired Concepts -> Retired Concept 2005 -> EWS-FLI1 Type 1

EWS-FLI1 Type 1 Definition

One allele of the transforming chimeric gene resulting from a t(11;22) translocation that is found frequently in patients with Ewing's sarcoma or primitive neuroectodermal tumors (PNET). EWS-FLI 1 type 1 encodes a protein, mTOR, that is a central regulator of translation and cell proliferation. mTOR activates the mitogen-activated protein kinase (MAPK) signaling pathway, resulting in neoplastic transformation. Antisense oligonucleotides that target EWS-FLI 1 type 1 have been used investigationally to treat this genetic anomaly, resulting in cell cycle arrest at G1 phase. (NCI04)

EWS-FLI1 Type 1 Synonyms

EWS/FLI 1 Type 1, EF-1, EF-1(EWS/FLI 1 Type 1), EWS/FLI 1 (type 1), EWS/FLI 1 Type 1 Fusion Gene

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