Eight-oxo-dGTPase
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Eight-oxo-dGTPase Definition
Human 7,8-dihydro-8-oxoguanine triphosphatase protein (197 aa, 23 kD - unprocessed precursor) is encoded by the nudix (nucleoside diphosphate linked moiety X)-type motif 1 gene (NUDT1). Isoforms of this soluble protein are localized to both the cytoplasm and mitochondria of the cell. It catalyzes the hydrolysis of 8-oxo-dGTP to yield 8-oxo-dGMP and diphosphate. Misincorporation of 8-oxo-dGTP into DNA can result in A:T to C:G transversion mutations. Therefore, this enzyme is considered to be antimutagenic.
Eight-oxo-dGTPase Synonyms
7,8-Dihydro-8-Oxoguanine Triphosphatase, 8-oxo-dGTPase, Nucleoside Diphosphate-Linked Moiety X Motif 1, Nudix Motif 1
Terms in Eight-oxo-dGTPase category
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