Elongin Binding Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Elongin Binding Protein

Elongin Binding Protein Definition

A product of the von Hippel Lindau tumor suppressor gene, Elongin Binding Protein (VHL) is a general transcription elongation factor that increases the rate at which RNA polymerase II transcribes DNA by suppressing polymerase pausing. VHL is part of a complex (VCB) that includes elongin B, elongin C, and cullin-2, proteins associated with transcriptional elongation and ubiquitination. VHL directly interacts with, and inhibits, SP1. VHL inhibits expression of hypoxia-inducing VEGF and GLUT1 genes. (from OMIM 193300 and NCI)

Elongin Binding Protein Synonyms

Elongin Binding Protein, G7 Protein, VHL, VHL Protein, von Hippel Lindau Tumor Supressor Protein

Terms in Elongin Binding Protein category

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