Cancer Terms

Ephrin Receptor-EphA3

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Ephrin Receptor-EphA3 Definition

The HEK receptor tyrosine kinase shows a high degree of homology with EPH and ELK RTKs. The largest subfamily of RTKs, EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). HEK expression appears restricted to lymphoid tumor cell lines, suggesting that HEK may contribute to lymphoid malignancies and normal lymphoid function and differentiation. (from OMIM 179611 and NCI)

Ephrin Receptor-EphA3 Synonyms

Ephrin Receptor EphA3, EPA3, EPH-Like Tyrosine Kinase 1, EPHA3, Ephrin Type-A Receptor 3, HEK, Human Embryo Kinase 1, Tyrosine Protein Kinase Receptor ETK1

Terms in Ephrin Receptor-EphA3 category



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