Epithelial Discoidin Domain Receptor-1

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Epithelial Discoidin Domain Receptor-1 Definition

Encoded by human DDR1 Gene (PTK Family, Insulin Receptor Subfamily), 913-amino acid 101 kD (precursor) Epithelial Discoidin Domain Receptor 1, a type I membrane protein homolog of mouse Ptk3, is largely expressed in epithelial cells of kidney, lung, gastrointestinal tract, and brain. DDR1 exhibits extracellular Discoidin I motifs; GLY/PRO-rich domains likely required for ligand or substrate interaction; a F5/8 type C domain; and a novel N-terminal region with homology to a factor VIII domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs - TRKA, TRKB, and TRKC - regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. (from Swiss-Prot Q08345 and NCI)

Epithelial Discoidin Domain Receptor-1 Synonyms

Epithelial Discoidin Domain Receptor 1, CD167A Antigen, Cell Adhesion Kinase, DDR1, Discoidin Domain Receptor, Discoidin Domain Receptor Family Member 1, Discoidin Receptor Tyrosine Kinase, Epithelial-Specific Receptor Kinase, Mammarian Carcinoma Kinase 10, NTRK4, Neuroepithelial Tyrosine Kinase, Neurotrophic Tyrosine Kinase Receptor Type 4, Protein-Tyrosine Kinase RTK 6, Receptor Tyrosine Kinase NEP, TRKE, Tyrosine Kinase DDR, Tyrosine Kinase Receptor E, Tyrosine-Protein Kinase CAK

Terms in Epithelial Discoidin Domain Receptor-1 category

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