ErbB-2 Inhibitor ARRY-380
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ErbB-2 Inhibitor ARRY-380 Definition
An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
ErbB-2 Inhibitor ARRY-380 Synonyms
ErbB-2 Inhibitor ARRY-380, ARRY-380
Terms in ErbB-2 Inhibitor ARRY-380 category
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