Cancer Terms

Erbstatin Analog

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Tyrosine Kinase Inhibitor -> Erbstatin Analog

Erbstatin Analog Definition

A cell-permeable analog of erbstatin, a compound isolated from Streptomyces that inhibits the autophosphorylation of epidermal growth factor receptor. Erbstatin analogue competitively inhibits epidermal growth factor receptor-associated tyrosine kinase, inhibiting the activation of v-abl tyrosine kinase. In addition, this agent has induced apoptosis in mouse thymocytes and inhibits the G2/M phase of the cell cycle. (NCI)

Erbstatin Analog Synonyms

Methyl 2,5-dihydroxycinnamate, 3-(2,5-Dihydroxyphenyl)-2-propenoic Acid Methyl Ester, ALX-270-098, Methyl-2,5-dihydroxycinnamate

Terms in Erbstatin Analog category



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