Erk1 Erk2 MAPK Signaling Pathway
Cancer Terms ->
Biochemical Pathway ->
Signaling Pathways -> Erk1 Erk2 MAPK Signaling Pathway
Erk1 Erk2 MAPK Signaling Pathway Definition
The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network.
Erk1 Erk2 MAPK Signaling Pathway Synonyms
Erk1/Erk2 MAPK Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway
Terms in Erk1 Erk2 MAPK Signaling Pathway category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.