Ewing Sarcoma Breakpoint Region-1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> RNA Binding Protein -> Ewing Sarcoma Breakpoint Region-1 Protein

Ewing Sarcoma Breakpoint Region-1 Protein Definition

Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor. EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation domain. The RNA-binding activity is localized to a C-terminal RGG box. EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7. EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation. Two isoforms of the EWS protein are produced by differential splicing. (from SWISS-PROT Q01844 and NCI)

Ewing Sarcoma Breakpoint Region-1 Protein Synonyms

Ewing Sarcoma Breakpoint Region 1 Protein, EWS Protein, EWSR1, EWSR1 Protein, RNA Binding Protein EWS

Terms in Ewing Sarcoma Breakpoint Region-1 Protein category

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