Cancer Terms

Exatecan Mesylate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> Camptothecin Analogue -> Exatecan Mesylate

Exatecan Mesylate Definition

A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)

Exatecan Mesylate Synonyms

Exatecan Mesylate, DX-8951f, EXATECAN MESYLATE, Exatecan Mesylate Hydrate, exatecan mesylate

Terms in Exatecan Mesylate category



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