Cancer Terms

Exostosin-Like-2 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Glycosyltransferase -> Exostosin-Like-2 Protein

Exostosin-Like-2 Protein Definition

Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)

Exostosin-Like-2 Protein Synonyms

Exostosin-Like 2 Protein, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-Related Protein 2, EXTL2

Terms in Exostosin-Like-2 Protein category



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