Experimental Allergic Encephalomyelitis
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Experimental Allergic Encephalomyelitis Definition
An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenised brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis. --2004
Experimental Allergic Encephalomyelitis Synonyms
Experimental Allergic Encephalomyelitis, EAE
Terms in Experimental Allergic Encephalomyelitis category
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