FAK Inhibitor PF-04554878
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FAK Inhibitor PF-04554878 Definition
An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation.
FAK Inhibitor PF-04554878 Synonyms
FAK Inhibitor PF-04554878, Focal Adhesion Kinase Inhibitor PF-04554878, PF-04554878
Terms in FAK Inhibitor PF-04554878 category
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