Cancer Terms

FAK Inhibitor PF-04554878

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Tyrosine Kinase Inhibitor -> FAK Inhibitor PF-04554878

FAK Inhibitor PF-04554878 Definition

An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation.

FAK Inhibitor PF-04554878 Synonyms

FAK Inhibitor PF-04554878, Focal Adhesion Kinase Inhibitor PF-04554878, PF-04554878

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