FAS Ligand
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FAS Ligand Definition
FAS ligand is a TNF family, type II transmembrane protein expressed on many cell types and secreted from T-cells upon TCR ligation by MHC/peptide complexes residing on antigen presenting cells. FAS ligand triggers cell death by binding to the cell surface receptor FAS, another transmembrane protein member of the TNF receptor family. FAS ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated cytotoxicity, and in the liver, lung, ovary, and heart, where its function is unclear. (from OMIM 134638 and NCI)
FAS Ligand Synonyms
Tumor Necrosis Factor Ligand Superfamily Member 6, Apoptosis Antigen Ligand 1, CD178 Antigen, CD95 Ligand, FAS-Ligand, FASL, Fas Ligand, Fas-L, TNFSF6
Terms in FAS Ligand category
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