FGFR Substrate-3
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FGFR Substrate-3 Definition
Encoded by human FRS3 Gene, 492-aa 54-kDa plasma membrane-associated FGFR Substrate 3 is an FGFR substrate that links FGFR stimulation to RAS activators. Similar (49% identical) to FRS2, FRS3 also contains a myristylation sequence, a PTB domain, and Tyr-containing motifs that govern GRB2 and SHP2 recruitment. FRS2 and FRS3 bind directly to FGFR1; an FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. (NCI)
FGFR Substrate-3 Synonyms
FGFR Substrate 3, FRS2-Beta, FRS2B, FRS3, Fibroblast Growth Factor Receptor Substrate 3, SNT2, SUC1-Associated Neurotrophic Factor Target 2
Terms in FGFR Substrate-3 category
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