Cancer Terms

Fazarabine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimetabolite -> Pyrimidine Antagonist -> Fazarabine

Fazarabine Definition

An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. (NCI04)

Fazarabine Synonyms

Fazarabine, 1,3, 5-Triazin-2(1H)-one, 4-Amino-1-beta-D- arabinofuranosyl- (9CI), 1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI), 1-.beta.-D-Arabinofuranosyl-5-azacytosine, 1-Beta-D-arabinofuranosyl-5-azacytosine, Ara AC, FAZARABINE, Kymarabine, ara-AC, fazarabine

Terms in Fazarabine category



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