Fc-Gamma Receptor-II

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Fc Receptor -> Fc-Gamma Receptor-II

Fc-Gamma Receptor-II Definition

Generally expressed in monocytes, macrophages, polymorphonuclear cells, NK cells, T- and B-lymphocytes, and platelets, Fc-Gamma Receptors II are type I cell surface membrane protein low affinity receptors for aggregated IgG Fc region with 2 extracellular IgC2 domains and cytoplasmic ITIM or ITAM motifs involved in cell activation upon receptor aggregation. IgG binding initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. (NCI)

Fc-Gamma Receptor-II Synonyms

Fc-Gamma Receptor II

Terms in Fc-Gamma Receptor-II category

IgG-Fc-Receptor-IIA
IgG-Fc-Receptor-IIB
IgG-Fc-Receptor-IIC