Fenretinide Lipid Matrix
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Fenretinide Lipid Matrix Definition
An orally-active, powder formulation of a synthetic phenylretinamide analogue of retinol with potential chemopreventive and antineoplastic activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types, including colon, breast, and prostate carcinoma, as well as neuroblastoma. Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death via effectors, ganglioside GD3, and reactive oxygen species. Compared to the capsule form, the powder contains a mixture of wheat flour, fats, and sugar that may contribute to the enhanced bioavailability of fenretinide and may ultimately lead to an improvement in efficacy.
Fenretinide Lipid Matrix Synonyms
Fenretinide Lipid Matrix, Fenretinide LXS, Fenretinide Lym-X-Sorb
Terms in Fenretinide Lipid Matrix category
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