Fibronectin
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Gene Product ->
Protein ->
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Extracellular Matrix Protein -> Fibronectin
Fibronectin Definition
Encoded as alternative isoforms by human FN1 Gene, 2386-aa 262.6-kD Fibronectin precursor is a sulfated disulfide bound glycoprotein with multiple type I, II, and III fibronectin domains. MSF FN70 is an isoform. Plasma (hepatocytes) and cellular (fibroblasts and epithelia) FN differ in activity. Cell surface cellular FN (di/multimeric) is deposited in the ECM. FN is involved in embryogenesis, cell adhesion, migration, and motility, opsonization, wound healing, coagulation, host defense, cell shape, and metastasis. It stimulates endocytosis and may promote clearance of C1q-coated immune complexes. FN binds cell surface integrin, C1q, collagen, fibrin, hyaluronic acid, heparin, FBLN1, and actin. Most cells depend on FN to bind collagen. Talin-1 may link FN/Integrin with the actin cytoskeleton. FN may promote contact inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Fibronectin Synonyms
Fibronectin, CIG, Cold-Insoluble Globulin, FN, FN1, FNZ, Fibronectin 1, LETS, LETS Protein, Large External Transformation-Sensitive Protein
Terms in Fibronectin category
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